Researchers have reported that increased consumption of juices and sweetened beverages is associated with cardiovascular disease and increased mortality among the overweight. The REGARDS study involved 17,930 participants age 45 years and older who were followed for an average of 6,9 years. There were 1465 deaths of whom 279 were associated with coronary artery disease. Those who drink more sweetened beverages and fruit juices doubled their risk of death from coronary vascular disease compared to those who consumed the least amount. This effect was strongest among obese patients. 
These results were reported in the American Heart Association's Epidemiology and Prevention Scientific Sessions 2018.
Over the mean follow-up period of 6.9 years, there were a total of 1465 all-cause deaths and 279 coronary heart disease deaths among the 17,930 participants.
The risk of coronary vascular disease was highest among those who consumed a mean of 20 ounces of juices and sweetened beverages. (Hazard ratio [HR], 2.0; 95% CI, 1.12 - 3.54) compared with those who consumed a mean of 0.8 ounces. Persons with a BMI between 25 and 29,9 also had increased mortality associated with increased juice and sweetened beverage consumption (HR, 1.12; 95% CI, 1.02 - 1.22; P = .04),
There are many explanations for this phenomenon. Increased sweetened beverage and juice consumption leads to increased insulin stimulation (due to glucose), increased hepatic gluconeogenesis, advanced glycation end products, and increased triglyceride levels (due to fructose and glucose) all of which contribute to formation of oxidized LDL, atherosclerosis and heart failure. 
 Collin L, Safford M, Vaccarino V and Welsh J. Abstract P235: Sugar-Sweetened Beverage and Food Intake and Mortality Risk Among U.S. Adults Circulation, 2018;137:AP235, originally published March 21, 2018
 Basta G, Schmidt AM, De Caterina R; Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes, Cardiovascular Research, Volume 63, Issue 4, 1 September 2004, Pages 582–592